An AnAlysis of pRotective AnD moDifiAble fActoRs

Acknowledgements Chapter 1 photo – Adela Hernandez, Federacion Mexicana de Alzheimer (FedMA) Chapter 2, 3, 4 photos – bupa Chapter 6 photo – Hong Kong Alzheimer's disease Association Cover and chapter 5 photos – iStock design-david o'Connor-2 Leg length and head circumference, early-life events Chapter 3 dr Matthew prina 1,2 richard pender 2 dr Cleusa Ferri 3 dr diego r. Mazzotti 3 prof emiliano Albanese 4 1 Depression; 2 Anxiety disorders; 3 Sleep disorders; 4 Psychological distress: personality and life events Chapter 4 dr Cleusa Ferri 1 dr ronaldo d. piovezan 1 Ivan padilla 1 prof Martin prince 1,3 prof emiliano Albanese 2,3 dr Matthew prina 3 1 Smoking and alcohol; 2 Physical activity and cognitive stimulation; 3 Diet Chapter 5 prof Martin prince 1,2,3,4 prof José A. Luchsinger 4 prof emiliano Albanese 2 1 Hypertension; 2 Obesity; 3 Cholesterol; 4 Diabetes Chapter 6 prof Martin prince dr Maëlenn Guerchet dr Matthew prina prof emiliano Albanese foreword Dementia, including Alzheimer's disease, remains one of the biggest global public health challenges facing our generation. The number of people living with dementia worldwide today is estimated at 44 million, set to almost double by 2030 and more than triple by 2050. The global cost of dementia was estimated in 2010 at US $604 billion, and this is only set to rise. Given this epidemic scale, and with no known cure, it's crucial that we look at what we can do to reduce the risk or delay the onset of developing the disease. We believe that Alzheimer's disease and other forms of dementia must become a national and international public health priority. Governments must develop adequate strategies to deal with the epidemic holistically – including tackling both reduction in risk for future generations, and adequately caring for people living with the condition and supporting their friends and family. As the only worldwide international federation of Alzheimer associations and global voice on dementia, and the largest international provider of specialist dementia care, we are committed to changing the way the world thinks about dementia. One way we will do this is by campaigning for national dementia plans which have greater emphasis on improved brain health, as well as enabling those who have dementia to live well. To make this happen, and lessen the impact of dementia on individuals and society, there is enormous possibility in a comprehensive approach from all sectors, including health, business, …